HIV-1 and human genetic variation.

Details

Serval ID
serval:BIB_16DF9AACD3B9
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
HIV-1 and human genetic variation.
Journal
Nature reviews. Genetics
Author(s)
McLaren P.J., Fellay J.
ISSN
1471-0064 (Electronic)
ISSN-L
1471-0056
Publication state
In Press
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: aheadofprint
Abstract
Over the past four decades, research on the natural history of HIV infection has described how HIV wreaks havoc on human immunity and causes AIDS. HIV host genomic research, which aims to understand how human genetic variation affects our response to HIV infection, has progressed from early candidate gene studies to recent multi-omic efforts, benefiting from spectacular advances in sequencing technology and data science. In addition to invading cells and co-opting the host machinery for replication, HIV also stably integrates into our own genome. The study of the complex interactions between the human and retroviral genomes has improved our understanding of pathogenic mechanisms and suggested novel preventive and therapeutic approaches against HIV infection.
Pubmed
Web of science
Open Access
Yes
Create date
06/07/2021 12:46
Last modification date
10/07/2021 6:33
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