Innate receptors for adaptive immunity.
Détails
Télécharger: BIB_1618F2596A47.P001.pdf (1016.95 [Ko])
Etat: Public
Version: Author's accepted manuscript
Etat: Public
Version: Author's accepted manuscript
ID Serval
serval:BIB_1618F2596A47
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Innate receptors for adaptive immunity.
Périodique
Current Opinion in Microbiology
ISSN
1879-0364 (Electronic)
ISSN-L
1369-5274
Statut éditorial
Publié
Date de publication
2013
Volume
16
Numéro
3
Pages
296-302
Langue
anglais
Résumé
Pattern recognition receptors (PRRs) are commonly known as sensor proteins crucial for the early detection of microbial or host-derived stress signals by innate immune cells. Interestingly, some PRRs are also expressed and functional in cells of the adaptive immune system. These receptors provide lymphocytes with innate sensing abilities; for example, B cells express Toll-like receptors, which are important for the humoral response. Strikingly, certain other NOD-like receptors are not only highly expressed in adaptive immune cells, but also exert functions related specifically to adaptive immune system pathways, such as regulating antigen presentation. In this review, we will focus particularly on the current understanding of PRR functions intrinsic to B and T lymphocytes; a developing aspect of PRR biology.
Mots-clé
Animals, Arrestins/metabolism, Carrier Proteins/genetics, Carrier Proteins/metabolism, Caspase 1/metabolism, Cells, Cultured, Diabetes Mellitus, Type 2/drug therapy, Diabetes Mellitus, Type 2/etiology, Diet, High-Fat/adverse effects, Docosahexaenoic Acids/pharmacology, Eicosapentaenoic Acid/pharmacology, Enzyme Activation/drug effects, Fatty Acids, Omega-3/immunology, Inflammasomes/immunology, Inflammasomes/metabolism, Inflammation/prevention & control, Interleukin-1beta/metabolism, Macrophages/drug effects, Macrophages/immunology, Mice, Mice, Inbred C57BL, Mice, Knockout, Receptors, G-Protein-Coupled/metabolism
Pubmed
Web of science
Open Access
Oui
Création de la notice
13/12/2013 16:37
Dernière modification de la notice
20/08/2019 12:45