Salivary cortisol and five-year change in cognitive performance in non-demented elderly subjects: a population-based study.

Détails

ID Serval
serval:BIB_1611372EB072
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Salivary cortisol and five-year change in cognitive performance in non-demented elderly subjects: a population-based study.
Périodique
Neurobiology of aging
Auteur(s)
Ouanes S., Castelao E., von Gunten A., Kuehner C., Preisig M., Popp J.
ISSN
1558-1497 (Electronic)
ISSN-L
0197-4580
Statut éditorial
Publié
Date de publication
13/05/2020
Peer-reviewed
Oui
Volume
94
Pages
34-37
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Résumé
Elevated cortisol levels have been associated with poorer cognitive performance in cross-sectional studies; this may be both a factor contributing to neurodegeneration and cognitive decline and a result of developing brain pathologies. However, it is still unclear (1) whether cortisol measures predict later cognitive decline and (2) whether cortisol changes over the years might be associated with cognitive changes. We analyzed data from CoLaus/PsyCoLaus, a prospective population-based study. Salivary cortisol (4 different measures on 1 day) and neuropsychological assessments were performed at a first visit and a follow-up visit 5 years later in 625 dementia-free participants aged ≥65 years. Salivary cortisol levels at waking and 30 minutes after waking, as well as longitudinal changes in cortisol 30 minutes after waking, cortisol awakening response, and cortisol AM-PM difference were associated with decline in global cognition. After controlling for potential confounders, only longitudinal changes in cortisol 30 minutes after waking remained associated with cognitive decline. These mostly negative findings indicate absent or subtle association between salivary cortisol and cognitive decline.
Mots-clé
Cognition, Cognitive decline, Cortisol, Dementia, HPA axis, Memory
Pubmed
Création de la notice
25/06/2020 15:23
Dernière modification de la notice
15/09/2020 6:26
Données d'usage