Salivary cortisol and five-year change in cognitive performance in non-demented elderly subjects: a population-based study.

Details

Serval ID
serval:BIB_1611372EB072
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Salivary cortisol and five-year change in cognitive performance in non-demented elderly subjects: a population-based study.
Journal
Neurobiology of aging
Author(s)
Ouanes S., Castelao E., von Gunten A., Kuehner C., Preisig M., Popp J.
ISSN
1558-1497 (Electronic)
ISSN-L
0197-4580
Publication state
Published
Issued date
13/05/2020
Peer-reviewed
Oui
Volume
94
Pages
34-37
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
Elevated cortisol levels have been associated with poorer cognitive performance in cross-sectional studies; this may be both a factor contributing to neurodegeneration and cognitive decline and a result of developing brain pathologies. However, it is still unclear (1) whether cortisol measures predict later cognitive decline and (2) whether cortisol changes over the years might be associated with cognitive changes. We analyzed data from CoLaus/PsyCoLaus, a prospective population-based study. Salivary cortisol (4 different measures on 1 day) and neuropsychological assessments were performed at a first visit and a follow-up visit 5 years later in 625 dementia-free participants aged ≥65 years. Salivary cortisol levels at waking and 30 minutes after waking, as well as longitudinal changes in cortisol 30 minutes after waking, cortisol awakening response, and cortisol AM-PM difference were associated with decline in global cognition. After controlling for potential confounders, only longitudinal changes in cortisol 30 minutes after waking remained associated with cognitive decline. These mostly negative findings indicate absent or subtle association between salivary cortisol and cognitive decline.
Keywords
Cognition, Cognitive decline, Cortisol, Dementia, HPA axis, Memory
Pubmed
Create date
25/06/2020 14:23
Last modification date
15/09/2020 5:26
Usage data