Clonal dominance among T-lymphocyte infiltrates in arthritis.

Détails

ID Serval
serval:BIB_158B147C7187
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Clonal dominance among T-lymphocyte infiltrates in arthritis.
Périodique
Proceedings of the National Academy of Sciences of the United States of America
Auteur⸱e⸱s
Stamenkovic I., Stegagno M., Wright K.A., Krane S.M., Amento E.P., Colvin R.B., Duquesnoy R.J., Kurnick J.T.
ISSN
0027-8424[print], 0027-8424[linking]
Statut éditorial
Publié
Date de publication
1988
Volume
85
Numéro
4
Pages
1179-1183
Langue
anglais
Notes
Publication types: Journal Article
Résumé
Synovial membranes in patients with rheumatoid arthritis as well as other types of chronic destructive inflammatory arthritis contain infiltrates of activated T lymphocytes that probably contribute to the pathogenesis of the disease. In an effort to elucidate the nature of these infiltrates, interleukin 2 (IL-2)-responsive T lymphocytes were grown out of synovial fragments from 14 patients undergoing surgery for advanced destructive inflammatory joint disease. Eleven of the samples examined were from patients with classical rheumatoid arthritis, while three others were obtained from individuals with clinical osteoarthritis. Southern blot analysis of T-cell receptor (TCR) beta-chain genes in 13 of 14 cultures showed distinct rearrangements, indicating that each culture was characterized by the predominance of a limited number of clones. T-cell populations from peripheral blood stimulated with a variety of activators and expanded with IL-2 did not demonstrate evidence of similar clonality in long-term culture. These results suggest that a limited number of activated T-cell clones predominate at the site of tissue injury in rheumatoid synovial membranes as well as in other types of destructive inflammatory joint disease. Further characterization of these T-cell clones may aid our understanding of the pathogenesis of these rheumatic disorders.
Mots-clé
Arthritis, Rheumatoid/pathology, Cells, Cultured, Clone Cells/drug effects, Clone Cells/pathology, DNA/analysis, Humans, Interleukin-2/pharmacology, Lymphocyte Activation, Osteoarthritis/pathology, Receptors, Antigen, T-Cell/genetics, Receptors, Antigen, T-Cell, alpha-beta, Synovial Membrane/pathology, T-Lymphocytes/drug effects, T-Lymphocytes/pathology
Pubmed
Création de la notice
25/08/2010 15:55
Dernière modification de la notice
20/08/2019 13:44
Données d'usage