IL-13 induces expression of CD36 in human monocytes through PPARgamma activation.

Détails

ID Serval
serval:BIB_14D7609ACF2B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
IL-13 induces expression of CD36 in human monocytes through PPARgamma activation.
Périodique
European Journal of Immunology
Auteur(s)
Berry A., Balard P., Coste A., Olagnier D., Lagane C., Authier H., Benoit-Vical F., Lepert J.C., Séguéla J.P., Magnaval J.F., Chambon P., Metzger D., Desvergne B., Wahli W., Auwerx J., Pipy B.
ISSN
0014-2980[print], 0014-2980[linking]
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
37
Numéro
6
Pages
1642-1652
Langue
anglais
Résumé
The class B scavenger receptor CD36 is a component of the pattern recognition receptors on monocytes that recognizes a variety of molecules. CD36 expression in monocytes depends on exposure to soluble mediators. We demonstrate here that CD36 expression is induced in human monocytes following exposure to IL-13, a Th2 cytokine, via the peroxisome proliferator-activated receptor (PPAR)gamma pathway. Induction of CD36 protein was paralleled by an increase in CD36 mRNA. The PPARgamma pathway was demonstrated using transfection of a PPARgamma expression plasmid into the murine macrophage cell line RAW264.7, expressing very low levels of PPARgamma, and in peritoneal macrophages from PPARgamma-conditional null mice. We also show that CD36 induction by IL-13 via PPARgamma is dependent on phospholipase A2 activation and that IL-13 induces the production of endogenous 15-deoxy-Delta12,14-prostaglandin J2, an endogenous PPARgamma ligand, and its nuclear localization in human monocytes. Finally, we demonstrate that CD36 and PPARgamma are involved in IL-13-mediated phagocytosis of Plasmodium falciparum-parasitized erythrocytes. These results reveal a novel role for PPARgamma in the alternative activation of monocytes by IL-13, suggesting that endogenous PPARgamma ligands, produced by phospholipase A2 activation, could contribute to the biochemical and cellular functions of CD36.
Mots-clé
Anilides/pharmacology, Animals, Antigens, CD36/genetics, Antigens, CD36/metabolism, Arachidonic Acids/pharmacology, Cell Line, Tumor, DNA/metabolism, Enzyme Inhibitors/pharmacology, Erythrocytes/drug effects, Erythrocytes/parasitology, Gene Expression/drug effects, Humans, Hypoglycemic Agents/pharmacology, Interleukin-13/pharmacology, Macrophages/drug effects, Macrophages/metabolism, Macrophages, Peritoneal/drug effects, Macrophages, Peritoneal/metabolism, Mice, Monocytes/drug effects, Monocytes/metabolism, PPAR gamma/agonists, PPAR gamma/antagonists & inhibitors, Phagocytosis/drug effects, Phospholipases A/antagonists & inhibitors, Phospholipases A2, Phosphonic Acids/pharmacology, Plasmodium falciparum/physiology, Prostaglandin D2/analogs & derivatives, Prostaglandin D2/metabolism, Protein Binding/drug effects, Thiazolidinediones/pharmacology, Transfection
Pubmed
Web of science
Création de la notice
24/01/2008 16:26
Dernière modification de la notice
20/08/2019 13:43
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