Absence of RNA-binding protein FXR2P prevents prolonged phase of kainate-induced seizures.
Détails
Etat: Public
Version: Final published version
Licence: CC BY-NC-ND 4.0
ID Serval
serval:BIB_149216241C09
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Absence of RNA-binding protein FXR2P prevents prolonged phase of kainate-induced seizures.
Périodique
EMBO reports
ISSN
1469-3178 (Electronic)
ISSN-L
1469-221X
Statut éditorial
Publié
Date de publication
07/04/2021
Peer-reviewed
Oui
Volume
22
Numéro
4
Pages
e51404
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
Status epilepticus (SE) is a condition in which seizures are not self-terminating and thereby pose a serious threat to the patient's life. The molecular mechanisms underlying SE are likely heterogeneous and not well understood. Here, we reveal a role for the RNA-binding protein Fragile X-Related Protein 2 (FXR2P) in SE. Fxr2 KO mice display reduced sensitivity specifically to kainic acid-induced SE. Immunoprecipitation of FXR2P coupled to next-generation sequencing of associated mRNAs shows that FXR2P targets are enriched in genes that encode glutamatergic post-synaptic components. Of note, the FXR2P target transcriptome has a significant overlap with epilepsy and SE risk genes. In addition, Fxr2 KO mice fail to show sustained ERK1/2 phosphorylation induced by KA and present reduced burst activity in the hippocampus. Taken together, our findings show that the absence of FXR2P decreases the expression of glutamatergic proteins, and this decrease might prevent self-sustained seizures.
Mots-clé
ERK signaling, FXR2P, glutamatergic synapses, kainic acid, status epilepticus
Pubmed
Web of science
Open Access
Oui
Création de la notice
02/04/2021 14:47
Dernière modification de la notice
12/01/2022 8:08