Absence of RNA-binding protein FXR2P prevents prolonged phase of kainate-induced seizures.

Details

Serval ID
serval:BIB_149216241C09
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Absence of RNA-binding protein FXR2P prevents prolonged phase of kainate-induced seizures.
Journal
EMBO reports
Author(s)
Lo A.C., Rajan N., Gastaldo D., Telley L., Hilal M.L., Buzzi A., Simonato M., Achsel T., Bagni C.
ISSN
1469-3178 (Electronic)
ISSN-L
1469-221X
Publication state
In Press
Peer-reviewed
Oui
Pages
e51404
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
Status epilepticus (SE) is a condition in which seizures are not self-terminating and thereby pose a serious threat to the patient's life. The molecular mechanisms underlying SE are likely heterogeneous and not well understood. Here, we reveal a role for the RNA-binding protein Fragile X-Related Protein 2 (FXR2P) in SE. Fxr2 KO mice display reduced sensitivity specifically to kainic acid-induced SE. Immunoprecipitation of FXR2P coupled to next-generation sequencing of associated mRNAs shows that FXR2P targets are enriched in genes that encode glutamatergic post-synaptic components. Of note, the FXR2P target transcriptome has a significant overlap with epilepsy and SE risk genes. In addition, Fxr2 KO mice fail to show sustained ERK1/2 phosphorylation induced by KA and present reduced burst activity in the hippocampus. Taken together, our findings show that the absence of FXR2P decreases the expression of glutamatergic proteins, and this decrease might prevent self-sustained seizures.
Keywords
ERK signaling, FXR2P, glutamatergic synapses, kainic acid, status epilepticus
Pubmed
Open Access
Yes
Create date
02/04/2021 14:47
Last modification date
09/04/2021 6:35
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