Increasing prevalence of obesity and diabetes among patients evaluated for liver transplantation in a Swiss tertiary referral center: a 10-year retrospective analysis.

Détails

Ressource 1Télécharger: smw_152_w30138.pdf (1931.54 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY-NC-SA 4.0
ID Serval
serval:BIB_14011818DC4B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Increasing prevalence of obesity and diabetes among patients evaluated for liver transplantation in a Swiss tertiary referral center: a 10-year retrospective analysis.
Périodique
Swiss medical weekly
Auteur⸱e⸱s
Kasmi S., Artru F., Barbosa J.V., Deibel A.R., Favre L., Peuble C., Saouli A.C., Goossens N., Müllhaupt B., Pascual M., Moradpour D., Vionnet J., Fraga M.
ISSN
1424-3997 (Electronic)
ISSN-L
0036-7672
Statut éditorial
Publié
Date de publication
28/02/2022
Peer-reviewed
Oui
Volume
152
Pages
w30138
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
Non-alcoholic fatty liver disease (NAFLD) is now the first cause of chronic liver disease in developed countries. We aimed to assess trends in the prevalence of obesity, type 2 diabetes mellitus (T2DM) and NAFLD in patients undergoing liver transplantation evaluation and to assess whether obese patients were less likely to be listed or had an increased drop-out rate after listing.
We conducted a retrospective study of all consecutive patients who underwent liver transplantation evaluation at a Swiss tertiary referral centre between January 2009 and March 2020.
A total of 242 patients were included, 83% were male. The median age was 59 years (IQR, 51-64 years). The most common causes of end-stage liver disease were viral hepatitis (28%), alcoholic liver disease (21%) and NAFLD (12%). Obesity was present in 28% of our cohort, with a significant increase over time. Prevalence of type 2 diabetes mellitus followed the same trend (p = 0.02). The proportions of non-listed and listed obese patients did not differ (21% vs. 30% respectively; p = 0.3).
The prevalence of obesity and type 2 diabetes mellitus significantly increased over our study period. Obese patients had similar chances of being listed. The landscape of liver transplantation indications is shifting towards NAFLD, highlighting the urgent need to prevent NAFLD progression.
Pubmed
Création de la notice
07/03/2022 11:03
Dernière modification de la notice
13/08/2022 6:08
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