Increasing prevalence of obesity and diabetes among patients evaluated for liver transplantation in a Swiss tertiary referral center: a 10-year retrospective analysis.

Details

Serval ID
serval:BIB_14011818DC4B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Increasing prevalence of obesity and diabetes among patients evaluated for liver transplantation in a Swiss tertiary referral center: a 10-year retrospective analysis.
Journal
Swiss medical weekly
Author(s)
Kasmi S., Artru F., Barbosa J.V., Deibel A.R., Favre L., Peuble C., Saouli A.C., Goossens N., Müllhaupt B., Pascual M., Moradpour D., Vionnet J., Fraga M.
ISSN
1424-3997 (Electronic)
ISSN-L
0036-7672
Publication state
Published
Issued date
28/02/2022
Peer-reviewed
Oui
Volume
152
Pages
w30138
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Non-alcoholic fatty liver disease (NAFLD) is now the first cause of chronic liver disease in developed countries. We aimed to assess trends in the prevalence of obesity, type 2 diabetes mellitus (T2DM) and NAFLD in patients undergoing liver transplantation evaluation and to assess whether obese patients were less likely to be listed or had an increased drop-out rate after listing.
We conducted a retrospective study of all consecutive patients who underwent liver transplantation evaluation at a Swiss tertiary referral centre between January 2009 and March 2020.
A total of 242 patients were included, 83% were male. The median age was 59 years (IQR, 51-64 years). The most common causes of end-stage liver disease were viral hepatitis (28%), alcoholic liver disease (21%) and NAFLD (12%). Obesity was present in 28% of our cohort, with a significant increase over time. Prevalence of type 2 diabetes mellitus followed the same trend (p = 0.02). The proportions of non-listed and listed obese patients did not differ (21% vs. 30% respectively; p = 0.3).
The prevalence of obesity and type 2 diabetes mellitus significantly increased over our study period. Obese patients had similar chances of being listed. The landscape of liver transplantation indications is shifting towards NAFLD, highlighting the urgent need to prevent NAFLD progression.
Pubmed
Create date
07/03/2022 12:03
Last modification date
11/03/2022 7:33
Usage data