Lack of evidence for the dichotomy of TH1 and TH2 predominance in HIV-infected individuals

Détails

ID Serval
serval:BIB_13E38F10C5DA
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Lack of evidence for the dichotomy of TH1 and TH2 predominance in HIV-infected individuals
Périodique
Science
Auteur(s)
Graziosi  C., Pantaleo  G., Gantt  K. R., Fortin  J. P., Demarest  J. F., Cohen  O. J., Sekaly  R. P., Fauci  A. S.
ISSN
0036-8075 (Print)
Statut éditorial
Publié
Date de publication
07/1994
Volume
265
Numéro
5169
Pages
248-52
Notes
Comparative Study
Journal Article --- Old month value: Jul 8
Résumé
A switch from a T helper 1 (TH1) cytokine phenotype to a TH2 phenotype has been proposed as a critical element in the progression of human immunodeficiency virus (HIV) disease. Here, constitutive cytokine expression was analyzed in unfractionated and sorted cell populations isolated from peripheral blood and lymph nodes of HIV-infected individuals at different stages of disease. Expression of interleukin-2 (IL-2) and IL-4 was barely detectable (or undetectable) regardless of the stage of disease. CD8+ cells expressed large amounts of interferon gamma and IL-10, and the levels of these cytokines remained stably high throughout the course of infection. Furthermore, similar patterns of cytokine expression were observed after stimulation in vitro of purified CD4+ T cell populations obtained from HIV-infected individuals at different stages of disease. These results indicate that a switch from the TH1 to the TH2 cytokine phenotype does not occur during the progression of HIV disease.
Mots-clé
Antigens, CD8/analysis Apoptosis Cell Separation Cross-Sectional Studies HIV Infections/*immunology Humans Interferon Type II/*biosynthesis Interleukin-10/biosynthesis Interleukin-2/biosynthesis Interleukin-4/biosynthesis Interleukins/*biosynthesis Longitudinal Studies Lymph Nodes/immunology Lymphocyte Activation Phenotype T-Lymphocyte Subsets/cytology/*immunology T-Lymphocytes, Helper-Inducer/*immunology
Pubmed
Web of science
Création de la notice
25/01/2008 15:58
Dernière modification de la notice
20/08/2019 13:42
Données d'usage