Lack of evidence for the dichotomy of TH1 and TH2 predominance in HIV-infected individuals

Details

Serval ID
serval:BIB_13E38F10C5DA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Lack of evidence for the dichotomy of TH1 and TH2 predominance in HIV-infected individuals
Journal
Science
Author(s)
Graziosi  C., Pantaleo  G., Gantt  K. R., Fortin  J. P., Demarest  J. F., Cohen  O. J., Sekaly  R. P., Fauci  A. S.
ISSN
0036-8075 (Print)
Publication state
Published
Issued date
07/1994
Volume
265
Number
5169
Pages
248-52
Notes
Comparative Study
Journal Article --- Old month value: Jul 8
Abstract
A switch from a T helper 1 (TH1) cytokine phenotype to a TH2 phenotype has been proposed as a critical element in the progression of human immunodeficiency virus (HIV) disease. Here, constitutive cytokine expression was analyzed in unfractionated and sorted cell populations isolated from peripheral blood and lymph nodes of HIV-infected individuals at different stages of disease. Expression of interleukin-2 (IL-2) and IL-4 was barely detectable (or undetectable) regardless of the stage of disease. CD8+ cells expressed large amounts of interferon gamma and IL-10, and the levels of these cytokines remained stably high throughout the course of infection. Furthermore, similar patterns of cytokine expression were observed after stimulation in vitro of purified CD4+ T cell populations obtained from HIV-infected individuals at different stages of disease. These results indicate that a switch from the TH1 to the TH2 cytokine phenotype does not occur during the progression of HIV disease.
Keywords
Antigens, CD8/analysis Apoptosis Cell Separation Cross-Sectional Studies HIV Infections/*immunology Humans Interferon Type II/*biosynthesis Interleukin-10/biosynthesis Interleukin-2/biosynthesis Interleukin-4/biosynthesis Interleukins/*biosynthesis Longitudinal Studies Lymph Nodes/immunology Lymphocyte Activation Phenotype T-Lymphocyte Subsets/cytology/*immunology T-Lymphocytes, Helper-Inducer/*immunology
Pubmed
Web of science
Create date
25/01/2008 14:58
Last modification date
20/08/2019 12:42
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