Involvement of specific Lyt-2+ T cells in the immunological control of experimentally induced murine cutaneous leishmaniasis
Détails
ID Serval
serval:BIB_13CB0F53DEA6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Involvement of specific Lyt-2+ T cells in the immunological control of experimentally induced murine cutaneous leishmaniasis
Périodique
European Journal of Immunology
ISSN
0014-2980 (Print)
Statut éditorial
Publié
Date de publication
10/1987
Volume
17
Numéro
10
Pages
1429-33
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Oct
Research Support, Non-U.S. Gov't --- Old month value: Oct
Résumé
The involvement of Lyt-2+ T cells in the immunological control of cutaneous leishmaniasis was assessed by studying the course of the disease in mice in which the number of these cells was reduced by treatment with anti-Lyt-2 monoclonal antibody (mAb). Administration of anti-Lyt-2 mAb exacerbated Leishmania major-induced cutaneous lesions in both genetically resistant and susceptible mice. This effect correlated with a drastic reduction in the number of specific Lyt-2+ T cells generated during infection. These results, together with the observation that resistant mice possess higher numbers of specific Lyt-2+ T cells in lymph nodes draining their lesions than susceptible mice, 3 weeks after infection, indicate that Lyt-2+ T cells also play a role in the immunological control of Leishmania major-induced lesions.
Mots-clé
Animals
Antibodies, Monoclonal/immunology
Antigens, Differentiation, T-Lymphocyte/immunology
Antigens, Ly/*immunology
Hypersensitivity, Delayed
Interferon Type II/biosynthesis
Leishmania/immunology
Leishmaniasis/*immunology/prevention & control/therapy
Lymph Nodes/immunology
Mice
Mice, Inbred BALB C
Mice, Inbred CBA
Phenotype
T-Lymphocytes/*immunology
Pubmed
Web of science
Création de la notice
28/01/2008 12:14
Dernière modification de la notice
20/08/2019 13:42