Involvement of specific Lyt-2+ T cells in the immunological control of experimentally induced murine cutaneous leishmaniasis

Details

Serval ID
serval:BIB_13CB0F53DEA6
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Involvement of specific Lyt-2+ T cells in the immunological control of experimentally induced murine cutaneous leishmaniasis
Journal
European Journal of Immunology
Author(s)
Titus  R. G., Milon  G., Marchal  G., Vassalli  P., Cerottini  J. C., Louis  J. A.
ISSN
0014-2980 (Print)
Publication state
Published
Issued date
10/1987
Volume
17
Number
10
Pages
1429-33
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Oct
Abstract
The involvement of Lyt-2+ T cells in the immunological control of cutaneous leishmaniasis was assessed by studying the course of the disease in mice in which the number of these cells was reduced by treatment with anti-Lyt-2 monoclonal antibody (mAb). Administration of anti-Lyt-2 mAb exacerbated Leishmania major-induced cutaneous lesions in both genetically resistant and susceptible mice. This effect correlated with a drastic reduction in the number of specific Lyt-2+ T cells generated during infection. These results, together with the observation that resistant mice possess higher numbers of specific Lyt-2+ T cells in lymph nodes draining their lesions than susceptible mice, 3 weeks after infection, indicate that Lyt-2+ T cells also play a role in the immunological control of Leishmania major-induced lesions.
Keywords
Animals Antibodies, Monoclonal/immunology Antigens, Differentiation, T-Lymphocyte/immunology Antigens, Ly/*immunology Hypersensitivity, Delayed Interferon Type II/biosynthesis Leishmania/immunology Leishmaniasis/*immunology/prevention & control/therapy Lymph Nodes/immunology Mice Mice, Inbred BALB C Mice, Inbred CBA Phenotype T-Lymphocytes/*immunology
Pubmed
Web of science
Create date
28/01/2008 11:14
Last modification date
20/08/2019 12:42
Usage data