Cervicovaginal Tissue Residence Confers a Distinct Differentiation Program upon Memory CD8 T Cells.

Détails

ID Serval
serval:BIB_13570207C1EA
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Cervicovaginal Tissue Residence Confers a Distinct Differentiation Program upon Memory CD8 T Cells.
Périodique
Journal of immunology
Auteur(s)
Davé V.A., Cardozo-Ojeda E.F., Mair F., Erickson J., Woodward-Davis A.S., Koehne A., Soerens A., Czartoski J., Teague C., Potchen N., Oberle S., Zehn D., Schiffer J.T., Lund J.M., Prlic M.
ISSN
1550-6606 (Electronic)
ISSN-L
0022-1767
Statut éditorial
In Press
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Résumé
Tissue-resident memory CD8 T cells (CD8 T <sub>RM</sub> ) are critical for maintaining barrier immunity. CD8 T <sub>RM</sub> have been mainly studied in the skin, lung and gut, with recent studies suggesting that the signals that control tissue residence and phenotype are highly tissue dependent. We examined the T cell compartment in healthy human cervicovaginal tissue (CVT) and found that most CD8 T cells were granzyme B <sup>+</sup> and TCF-1 <sup>-</sup> To address if this phenotype is driven by CVT tissue residence, we used a mouse model to control for environmental factors. Using localized and systemic infection models, we found that CD8 T <sub>RM</sub> in the mouse CVT gradually acquired a granzyme B <sup>+</sup> , TCF-1 <sup>-</sup> phenotype as seen in human CVT. In contrast to CD8 T <sub>RM</sub> in the gut, these CD8 T <sub>RM</sub> were not stably maintained regardless of the initial infection route, which led to reductions in local immunity. Our data show that residence in the CVT is sufficient to progressively shape the size and function of its CD8 T <sub>RM</sub> compartment.
Pubmed
Web of science
Création de la notice
15/06/2021 16:09
Dernière modification de la notice
24/07/2021 6:34
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