Cervicovaginal Tissue Residence Confers a Distinct Differentiation Program upon Memory CD8 T Cells.

Details

Serval ID
serval:BIB_13570207C1EA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Cervicovaginal Tissue Residence Confers a Distinct Differentiation Program upon Memory CD8 T Cells.
Journal
Journal of immunology
Author(s)
Davé V.A., Cardozo-Ojeda E.F., Mair F., Erickson J., Woodward-Davis A.S., Koehne A., Soerens A., Czartoski J., Teague C., Potchen N., Oberle S., Zehn D., Schiffer J.T., Lund J.M., Prlic M.
ISSN
1550-6606 (Electronic)
ISSN-L
0022-1767
Publication state
In Press
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
Tissue-resident memory CD8 T cells (CD8 T <sub>RM</sub> ) are critical for maintaining barrier immunity. CD8 T <sub>RM</sub> have been mainly studied in the skin, lung and gut, with recent studies suggesting that the signals that control tissue residence and phenotype are highly tissue dependent. We examined the T cell compartment in healthy human cervicovaginal tissue (CVT) and found that most CD8 T cells were granzyme B <sup>+</sup> and TCF-1 <sup>-</sup> To address if this phenotype is driven by CVT tissue residence, we used a mouse model to control for environmental factors. Using localized and systemic infection models, we found that CD8 T <sub>RM</sub> in the mouse CVT gradually acquired a granzyme B <sup>+</sup> , TCF-1 <sup>-</sup> phenotype as seen in human CVT. In contrast to CD8 T <sub>RM</sub> in the gut, these CD8 T <sub>RM</sub> were not stably maintained regardless of the initial infection route, which led to reductions in local immunity. Our data show that residence in the CVT is sufficient to progressively shape the size and function of its CD8 T <sub>RM</sub> compartment.
Pubmed
Web of science
Create date
15/06/2021 16:09
Last modification date
24/07/2021 6:34
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