Protective effect of perindoprilat in the hypoxemia-induced renal dysfunction in the newborn rabbit.

Détails

ID Serval
serval:BIB_12760
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Protective effect of perindoprilat in the hypoxemia-induced renal dysfunction in the newborn rabbit.
Périodique
Pediatric Research
Auteur⸱e⸱s
Huet F., Semama D.S., Gouyon J.B., Guignard J.P.
ISSN
0031-3998
Statut éditorial
Publié
Date de publication
1999
Volume
45
Numéro
1
Pages
138-142
Langue
anglais
Résumé
The renal effects of acute hypoxemia and the ability of perindoprilat, a potent angiotensin-converting enzyme inhibitor, to prevent these effects were assessed in 31 anesthetized and mechanically ventilated newborn (5 to 8 d of age) rabbits. Renal blood flow (RBF) and GFR were determined by the clearances of para-aminohippuric acid and inulin, respectively. Each animal acted as its own control. In eight normoxemic rabbits (group 1), the i.v. infusion of saline did not change renal and hemodynamic functions. In eight additional rabbits, acute hypoxemia (PaO2= 40 mm Hg) induced a significant decrease in mean blood pressure (-8+/-2%), RBF (-36+/-3%), and GFR (-31+/-3%) and an increase in renal vascular resistance (+50+/-12%). A third group of newborn animals (n=7) was used to determine the renal effects of perindoprilat administration (20 microg/kg) under normoxemic conditions. RBF significantly increased (+15+/-2%) and renal vascular resistance significantly decreased (-15+/-3%), whereas GFR, mean blood pressure, and filtration fraction did not change significantly. In group 4 (n=7), perindoprilat infusion completely prevented the hypoxemia-induced alterations in GFR and renal vascular resistance and partially prevented the fall in RBF. These results demonstrate that angiotensin II modulates the renal immature microcirculation and that inhibition of its formation effectively prevents the hypoxemia-induced decrease in GFR.
Mots-clé
Angiotensin-Converting Enzyme Inhibitors/therapeutic use, Animals, Animals, Newborn, Anoxia/complications, Anoxia/drug therapy, Bradykinin/metabolism, Indoles/therapeutic use, Kidney Diseases/etiology, Kidney Diseases/metabolism, Rabbits
Pubmed
Web of science
Open Access
Oui
Création de la notice
19/11/2007 13:04
Dernière modification de la notice
20/08/2019 13:40
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