Protective effect of perindoprilat in the hypoxemia-induced renal dysfunction in the newborn rabbit.

Details

Serval ID
serval:BIB_12760
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Protective effect of perindoprilat in the hypoxemia-induced renal dysfunction in the newborn rabbit.
Journal
Pediatric Research
Author(s)
Huet F., Semama D.S., Gouyon J.B., Guignard J.P.
ISSN
0031-3998
Publication state
Published
Issued date
1999
Volume
45
Number
1
Pages
138-142
Language
english
Abstract
The renal effects of acute hypoxemia and the ability of perindoprilat, a potent angiotensin-converting enzyme inhibitor, to prevent these effects were assessed in 31 anesthetized and mechanically ventilated newborn (5 to 8 d of age) rabbits. Renal blood flow (RBF) and GFR were determined by the clearances of para-aminohippuric acid and inulin, respectively. Each animal acted as its own control. In eight normoxemic rabbits (group 1), the i.v. infusion of saline did not change renal and hemodynamic functions. In eight additional rabbits, acute hypoxemia (PaO2= 40 mm Hg) induced a significant decrease in mean blood pressure (-8+/-2%), RBF (-36+/-3%), and GFR (-31+/-3%) and an increase in renal vascular resistance (+50+/-12%). A third group of newborn animals (n=7) was used to determine the renal effects of perindoprilat administration (20 microg/kg) under normoxemic conditions. RBF significantly increased (+15+/-2%) and renal vascular resistance significantly decreased (-15+/-3%), whereas GFR, mean blood pressure, and filtration fraction did not change significantly. In group 4 (n=7), perindoprilat infusion completely prevented the hypoxemia-induced alterations in GFR and renal vascular resistance and partially prevented the fall in RBF. These results demonstrate that angiotensin II modulates the renal immature microcirculation and that inhibition of its formation effectively prevents the hypoxemia-induced decrease in GFR.
Keywords
Angiotensin-Converting Enzyme Inhibitors/therapeutic use, Animals, Animals, Newborn, Anoxia/complications, Anoxia/drug therapy, Bradykinin/metabolism, Indoles/therapeutic use, Kidney Diseases/etiology, Kidney Diseases/metabolism, Rabbits
Pubmed
Web of science
Open Access
Yes
Create date
19/11/2007 12:04
Last modification date
20/08/2019 12:40
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