Immunoglobulin classes in aquatic mammals. Characterization by serologic cross-reactivity, molecular size and binding of human free secretory component.

Détails

ID Serval
serval:BIB_10CC83E29DC8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Immunoglobulin classes in aquatic mammals. Characterization by serologic cross-reactivity, molecular size and binding of human free secretory component.
Périodique
Journal of Immunology
Auteur(s)
Nash D.R., Mach J.P.
ISSN
0022-1767 (Print)
ISSN-L
0022-1767
Statut éditorial
Publié
Date de publication
1971
Volume
107
Numéro
5
Pages
1424-1430
Langue
anglais
Résumé
On the basis of serologic cross-reactivity, three immunoglobulin classes homologous to human IgG, IgM and IgA were identified in two species of acquatic mammal representing the orders Cetacea (dolphin) and Pinnipedea (sea lion). Molecular size was estimated by sucrose density gradient ultracentrifugation and Sephadex G-200 chromatography, indicating a 7S IgG, 19S IgM and heterogeneous serum IgA. Human secretory component was readily bound to the IgM of both species and to an apparently lesser extent to the larger molecular size populations of IgA. No binding was observed with IgG. Several antisera specific for human γ-chains gave a single precipitin line with the sea lion IgG but when made to react with dolphin serum produced two lines, suggesting the presence of two different subclasses of IgG in this species.
Mots-clé
Animals, Antigen-Antibody Reactions, Autoradiography, Centrifugation, Density Gradient, Chromatography, Chromatography, Gel, Cross Reactions, Dolphins/immunology, Humans, Immunodiffusion, Immunoelectrophoresis, Immunoglobulin A/analysis, Immunoglobulin G/analysis, Immunoglobulin M, Immunoglobulins/analysis, Iodine Isotopes, Pinnipedia/immunology, Species Specificity
Pubmed
Web of science
Création de la notice
24/04/2013 9:55
Dernière modification de la notice
20/08/2019 12:38
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