Comparable Survival Between HIV+ and HIV- non-Hodgkin and Hodgkin Lymphoma Patients Undergoing Autologous Peripheral Blood Stem Cell Transplantation.

Détails

ID Serval
serval:BIB_1083AF5902E4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Comparable Survival Between HIV+ and HIV- non-Hodgkin and Hodgkin Lymphoma Patients Undergoing Autologous Peripheral Blood Stem Cell Transplantation.
Périodique
Blood
Auteur(s)
Díez-Martín J.L., Balsalobre P., Re A., Michieli M., Ribera J.M., Canals C., Conde E., Rosselet A., Gabriel I., Varela R., Allione B., Cwynarski K., Genet P., Espigado I., Biron P., Schmitz N., Hunter A.E., Ferrant A., Guillerm G., Hentrich M., Jurado M., Fernández P., Serrano D., Rossi G., Sureda A.
ISSN
1528-0020[electronic]
Statut éditorial
Publié
Date de publication
2009
Volume
113
Numéro
23
Pages
6011-6014
Langue
anglais
Résumé
Autologous stem cell transplantation (ASCT) has been successfully used in HIV-related lymphoma (HIV-Ly) patients on highly active antiretroviral therapy. We report the first comparative analysis between HIV-Ly and a matched cohort of HIV(-) lymphoma patients. This retrospective European Group for Blood and Marrow Transplantation study included 53 patients (66% non-Hodgkin and 34% Hodgkin lymphoma) within each cohort. Both groups were comparable except for the higher proportion of males, mixed-cellularity Hodgkin lymphoma and patients receiving granulocyte colony-stimulating factor before engraftment and a smaller proportion receiving total body irradiation-based conditioning within the HIV-Ly cohort. Incidence of relapse, overall survival, and progression-free survival were similar in both cohorts. A higher nonrelapse mortality within the first year after ASCT was observed in the HIV-Ly group (8% vs 2%), predominantly because of early bacterial infections, although this was not statistically significant and did not influence survival. Thus, within the highly active antiretroviral therapy era, HIV patients should be considered for ASCT according to the same criteria adopted for HIV(-) lymphoma patients.
Mots-clé
Adult, Female, HIV Infections/complications, HIV Infections/surgery, Hodgkin Disease/etiology, Hodgkin Disease/surgery, Humans, Male, Middle Aged, Peripheral Blood Stem Cell Transplantation, Survival Rate, Transplantation, Autologous
Pubmed
Web of science
Open Access
Oui
Création de la notice
09/02/2010 11:05
Dernière modification de la notice
20/08/2019 12:37
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