Comparable Survival Between HIV+ and HIV- non-Hodgkin and Hodgkin Lymphoma Patients Undergoing Autologous Peripheral Blood Stem Cell Transplantation.

Details

Serval ID
serval:BIB_1083AF5902E4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Comparable Survival Between HIV+ and HIV- non-Hodgkin and Hodgkin Lymphoma Patients Undergoing Autologous Peripheral Blood Stem Cell Transplantation.
Journal
Blood
Author(s)
Díez-Martín J.L., Balsalobre P., Re A., Michieli M., Ribera J.M., Canals C., Conde E., Rosselet A., Gabriel I., Varela R., Allione B., Cwynarski K., Genet P., Espigado I., Biron P., Schmitz N., Hunter A.E., Ferrant A., Guillerm G., Hentrich M., Jurado M., Fernández P., Serrano D., Rossi G., Sureda A.
ISSN
1528-0020[electronic]
Publication state
Published
Issued date
2009
Volume
113
Number
23
Pages
6011-6014
Language
english
Abstract
Autologous stem cell transplantation (ASCT) has been successfully used in HIV-related lymphoma (HIV-Ly) patients on highly active antiretroviral therapy. We report the first comparative analysis between HIV-Ly and a matched cohort of HIV(-) lymphoma patients. This retrospective European Group for Blood and Marrow Transplantation study included 53 patients (66% non-Hodgkin and 34% Hodgkin lymphoma) within each cohort. Both groups were comparable except for the higher proportion of males, mixed-cellularity Hodgkin lymphoma and patients receiving granulocyte colony-stimulating factor before engraftment and a smaller proportion receiving total body irradiation-based conditioning within the HIV-Ly cohort. Incidence of relapse, overall survival, and progression-free survival were similar in both cohorts. A higher nonrelapse mortality within the first year after ASCT was observed in the HIV-Ly group (8% vs 2%), predominantly because of early bacterial infections, although this was not statistically significant and did not influence survival. Thus, within the highly active antiretroviral therapy era, HIV patients should be considered for ASCT according to the same criteria adopted for HIV(-) lymphoma patients.
Keywords
Adult, Female, HIV Infections/complications, HIV Infections/surgery, Hodgkin Disease/etiology, Hodgkin Disease/surgery, Humans, Male, Middle Aged, Peripheral Blood Stem Cell Transplantation, Survival Rate, Transplantation, Autologous
Pubmed
Web of science
Open Access
Yes
Create date
09/02/2010 11:05
Last modification date
20/08/2019 12:37
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