Effects of a glucose meal on energy metabolism in patients with cirrhosis before and after liver transplantation.

Détails

ID Serval
serval:BIB_0F583CBA9126
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Effects of a glucose meal on energy metabolism in patients with cirrhosis before and after liver transplantation.
Périodique
Archives of surgery
Auteur(s)
Tappy L., Schneiter P., Chioléro R., Bettschart V., Gillet M.
ISSN
0004-0010
Statut éditorial
Publié
Date de publication
2001
Peer-reviewed
Oui
Volume
136
Numéro
1
Pages
80-4
Langue
anglais
Notes
Publication types: Journal Article - Publication Status: ppublish
Résumé
HYPOTHESIS: Liver transplantation results in hepatic denervation. This may produce alterations of liver energy and substrate metabolism, which may contribute to weight gain after liver transplantation. DESIGN: Prospective clinical study. SETTING: Liver transplantation clinics in a university hospital. PATIENTS: Seven nondiabetic patients with cirrhosis were recruited while on a waiting list for liver transplantation. Seven healthy subjects were recruited as controls. INTERVENTION: Orthotopic liver transplantation. MAIN OUTCOME MEASURES: Evaluation of energy and substrate metabolism after ingestion of a glucose load with indirect calorimetry was performed before, 2 to 6 weeks after, and 5 to 19 months after transplantation. Whole-body glucose oxidation and storage and glucose-induced thermogenesis were calculated. RESULTS: Patients with cirrhosis had modestly elevated resting energy expenditure and normal glucose-induced thermogenesis and postprandial glucose oxidation and storage. These measures remained unchanged after liver transplantation despite a significant increase in postprandial glycemia. Patients, however, gained an average of 3 kg of body weight after 5 to 19 months compared with their weight before transplantation. CONCLUSION: Liver denervation secondary to transplantation does not lead to alterations of energy metabolism after ingestion of a glucose load.
Mots-clé
Blood Glucose, Case-Control Studies, Energy Metabolism, Female, Follow-Up Studies, Glucose, Humans, Liver, Liver Cirrhosis, Liver Transplantation, Male, Middle Aged, Postoperative Period, Preoperative Care, Prospective Studies, Time Factors, Weight Gain
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 13:36
Dernière modification de la notice
20/08/2019 12:36
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