Effects of a glucose meal on energy metabolism in patients with cirrhosis before and after liver transplantation.

Details

Serval ID
serval:BIB_0F583CBA9126
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effects of a glucose meal on energy metabolism in patients with cirrhosis before and after liver transplantation.
Journal
Archives of surgery
Author(s)
Tappy L., Schneiter P., Chioléro R., Bettschart V., Gillet M.
ISSN
0004-0010
Publication state
Published
Issued date
2001
Peer-reviewed
Oui
Volume
136
Number
1
Pages
80-4
Language
english
Notes
Publication types: Journal Article - Publication Status: ppublish
Abstract
HYPOTHESIS: Liver transplantation results in hepatic denervation. This may produce alterations of liver energy and substrate metabolism, which may contribute to weight gain after liver transplantation. DESIGN: Prospective clinical study. SETTING: Liver transplantation clinics in a university hospital. PATIENTS: Seven nondiabetic patients with cirrhosis were recruited while on a waiting list for liver transplantation. Seven healthy subjects were recruited as controls. INTERVENTION: Orthotopic liver transplantation. MAIN OUTCOME MEASURES: Evaluation of energy and substrate metabolism after ingestion of a glucose load with indirect calorimetry was performed before, 2 to 6 weeks after, and 5 to 19 months after transplantation. Whole-body glucose oxidation and storage and glucose-induced thermogenesis were calculated. RESULTS: Patients with cirrhosis had modestly elevated resting energy expenditure and normal glucose-induced thermogenesis and postprandial glucose oxidation and storage. These measures remained unchanged after liver transplantation despite a significant increase in postprandial glycemia. Patients, however, gained an average of 3 kg of body weight after 5 to 19 months compared with their weight before transplantation. CONCLUSION: Liver denervation secondary to transplantation does not lead to alterations of energy metabolism after ingestion of a glucose load.
Keywords
Blood Glucose, Case-Control Studies, Energy Metabolism, Female, Follow-Up Studies, Glucose, Humans, Liver, Liver Cirrhosis, Liver Transplantation, Male, Middle Aged, Postoperative Period, Preoperative Care, Prospective Studies, Time Factors, Weight Gain
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 14:36
Last modification date
20/08/2019 13:36
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