Antifungal activities of SCY-078 (MK-3118) and standard antifungal agents against clinical non-Aspergillus mold isolates.

Détails

ID Serval
serval:BIB_0E049DEF76E3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Antifungal activities of SCY-078 (MK-3118) and standard antifungal agents against clinical non-Aspergillus mold isolates.
Périodique
Antimicrobial agents and chemotherapy
Auteur(s)
Lamoth F., Alexander B.D.
ISSN
1098-6596 (Electronic)
ISSN-L
0066-4804
Statut éditorial
Publié
Date de publication
07/2015
Peer-reviewed
Oui
Volume
59
Numéro
7
Pages
4308-4311
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
The limited armamentarium of active and oral antifungal drugs against emerging non-Aspergillus molds is of particular concern. Current antifungal agents and the new orally available beta-1,3-d-glucan synthase inhibitor SCY-078 were tested in vitro against 135 clinical non-Aspergillus mold isolates. Akin to echinocandins, SCY-078 showed no or poor activity against Mucoromycotina and Fusarium spp. However, SCY-078 was highly active against Paecilomyces variotii and was the only compound displaying some activity against notoriously panresistant Scedosporium prolificans.
Mots-clé
Amphotericin B/pharmacology, Antifungal Agents/pharmacology, Drug Resistance, Fungal, Echinocandins/pharmacology, Fungi/drug effects, Glucosyltransferases/antagonists & inhibitors, Glycosides/pharmacology, Humans, Microbial Sensitivity Tests, Mycoses/microbiology, Retrospective Studies, Triterpenes/pharmacology
Pubmed
Web of science
Open Access
Oui
Création de la notice
03/10/2019 7:44
Dernière modification de la notice
04/10/2019 5:26
Données d'usage