Antifungal activities of SCY-078 (MK-3118) and standard antifungal agents against clinical non-Aspergillus mold isolates.
Details
Serval ID
serval:BIB_0E049DEF76E3
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Antifungal activities of SCY-078 (MK-3118) and standard antifungal agents against clinical non-Aspergillus mold isolates.
Journal
Antimicrobial agents and chemotherapy
ISSN
1098-6596 (Electronic)
ISSN-L
0066-4804
Publication state
Published
Issued date
07/2015
Peer-reviewed
Oui
Volume
59
Number
7
Pages
4308-4311
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
The limited armamentarium of active and oral antifungal drugs against emerging non-Aspergillus molds is of particular concern. Current antifungal agents and the new orally available beta-1,3-d-glucan synthase inhibitor SCY-078 were tested in vitro against 135 clinical non-Aspergillus mold isolates. Akin to echinocandins, SCY-078 showed no or poor activity against Mucoromycotina and Fusarium spp. However, SCY-078 was highly active against Paecilomyces variotii and was the only compound displaying some activity against notoriously panresistant Scedosporium prolificans.
Keywords
Amphotericin B/pharmacology, Antifungal Agents/pharmacology, Drug Resistance, Fungal, Echinocandins/pharmacology, Fungi/drug effects, Glucosyltransferases/antagonists & inhibitors, Glycosides/pharmacology, Humans, Microbial Sensitivity Tests, Mycoses/microbiology, Retrospective Studies, Triterpenes/pharmacology
Pubmed
Web of science
Open Access
Yes
Create date
03/10/2019 7:44
Last modification date
04/10/2019 5:26
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