Fibronectin promotes lung colony formation in the mouse by B16 melanoma cells spheroids.

Détails

ID Serval
serval:BIB_0DDDEEBD5088
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Fibronectin promotes lung colony formation in the mouse by B16 melanoma cells spheroids.
Périodique
In Vivo (athens, Greece)
Auteur(s)
Coucke P., De Pauw-Gillet M.C., De Leval L., Noel A., Bassleer R., Foidart J.M.
ISSN
0258-851X[print], 0258-851X[linking]
Statut éditorial
Publié
Date de publication
1992
Volume
6
Numéro
5
Pages
481-486
Langue
anglais
Résumé
By microscopical observation and using an original method of automatic image analysis, we studied on histological sections the rate of lung colony formation after intravenous injection into the mouse of B16 melanoma cells previously cultivated in vitro as pure or mixed spheroids (B16 + 3T3 fibroblasts). The preincubation in vitro of pure spheroids with fibronectin significantly increased the percentages of lung section area occupied by tumors and the relative number of internal lung colonies. This effect of fibronectin was even more obvious when mixed spheroids were injected.
Mots-clé
3T3 Cells/transplantation, Animals, Cells, Cultured/transplantation, Fibronectins/pharmacology, Image Processing, Computer-Assisted, Injections, Intravenous, Lung Neoplasms/secondary, Melanoma, Experimental/pathology, Melanoma, Experimental/secondary, Mice, Mice, Inbred C57BL, Neoplasm Transplantation, Neoplastic Cells, Circulating, Organoids/drug effects, Tumor Cells, Cultured
Pubmed
Création de la notice
29/10/2010 8:59
Dernière modification de la notice
20/08/2019 13:34
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