Fibronectin promotes lung colony formation in the mouse by B16 melanoma cells spheroids.

Details

Serval ID
serval:BIB_0DDDEEBD5088
Type
Article: article from journal or magazin.
Collection
Publications
Title
Fibronectin promotes lung colony formation in the mouse by B16 melanoma cells spheroids.
Journal
In Vivo (athens, Greece)
Author(s)
Coucke P., De Pauw-Gillet M.C., De Leval L., Noel A., Bassleer R., Foidart J.M.
ISSN
0258-851X[print], 0258-851X[linking]
Publication state
Published
Issued date
1992
Volume
6
Number
5
Pages
481-486
Language
english
Abstract
By microscopical observation and using an original method of automatic image analysis, we studied on histological sections the rate of lung colony formation after intravenous injection into the mouse of B16 melanoma cells previously cultivated in vitro as pure or mixed spheroids (B16 + 3T3 fibroblasts). The preincubation in vitro of pure spheroids with fibronectin significantly increased the percentages of lung section area occupied by tumors and the relative number of internal lung colonies. This effect of fibronectin was even more obvious when mixed spheroids were injected.
Keywords
3T3 Cells/transplantation, Animals, Cells, Cultured/transplantation, Fibronectins/pharmacology, Image Processing, Computer-Assisted, Injections, Intravenous, Lung Neoplasms/secondary, Melanoma, Experimental/pathology, Melanoma, Experimental/secondary, Mice, Mice, Inbred C57BL, Neoplasm Transplantation, Neoplastic Cells, Circulating, Organoids/drug effects, Tumor Cells, Cultured
Pubmed
Create date
29/10/2010 8:59
Last modification date
20/08/2019 13:34
Usage data