Prospective comparison of 3 gamma-probes for sentinel lymph node detection in 200 breast cancer patients1
Détails
ID Serval
serval:BIB_0C97DC05109B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Prospective comparison of 3 gamma-probes for sentinel lymph node detection in 200 breast cancer patients1
Périodique
Journal of Nuclear Medicine
ISSN
0161-5505 (Print)
Statut éditorial
Publié
Date de publication
2005
Volume
46
Numéro
3
Pages
395-399
Notes
PT - Clinical Trial PT - Comparative Study PT - Controlled Clinical Trial PT - Journal Article PT - Validation Studies
Résumé
Previous reports have shown that axillary sentinel lymph node (ASLN) radiodetection allows accurate axillary staging for patients with early breast cancer. Radioguided surgery implies the use of a gamma-probe to count the emitted radioactivity of marked ASLNs. Several gamma-probes are commercially available, each with its own properties. The clinical impact of the type of gamma-probe used for ASLN radiodetection remains to be evaluated. METHODS: Three commercially available gamma-probes were evaluated: a scintillator with a bismuth germanate crystal (probe A), a semiconductor with a cadmium telluride crystal (probe B), and a semiconductor with a cadmium zinc telluride crystal (probe C). Two hundred patients with early breast cancer were prospectively enrolled to undergo ASLN radiodetection and axillary lymphadenectomy. ASLN mapping consisted of injecting (99m)Tc-sulfur-colloid around the tumor. For each patient, sentinel lymph nodes were counted successively with the 3 probes and the sensitivity of each gamma-probe was determined from ASLN residual activity. The results of detection rates and false-negative rates for each probe were compared. RESULTS: Mean residual ASLN activity was 52 kBq (range, 0.07-189 kBq). Sensitivity was compared among the 3 probes and found to be best for probe A. The detection rate of probe A was significantly better than that of probe B (93% vs. 86%, P = 0.05) but not different from that of probe C (93% vs. 90%). No differences in false-negative rates were observed among the 3 probes. CONCLUSION: ASLN detection rate depends on the type of gamma-probe used. Because failure to detect the ASLN leads to complete axillary lymphadenectomy, involving local morbidity and other sequelae, the type of gamma-probe must be considered important for sentinel lymph node radiodetection
Mots-clé
Breast/Breast Neoplasms/Equipment Design/Equipment Failure Analysis/Female/France/Gamma Cameras/Humans/instrumentation/Lymph Nodes/Lymphatic Metastasis/methods/Middle Aged/Pathology/radionuclide imaging/Reproducibility of Results/Sensitivity and Specificity/Sentinel Lymph Node Biopsy/surgery/Surgery,Computer-Assisted/Technology Assessment,Biomedical
Pubmed
Web of science
Création de la notice
29/01/2008 19:36
Dernière modification de la notice
20/08/2019 13:34