Differential subcellular localization of phosphorylated neurofilament and tau proteins in degenerating neurons of the human entorhinal cortex.

Détails

ID Serval
serval:BIB_0BE226325C15
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Differential subcellular localization of phosphorylated neurofilament and tau proteins in degenerating neurons of the human entorhinal cortex.
Périodique
Neuroreport
Auteur(s)
Porchet R., Probst A., Dráberová E., Dráber P., Riederer I.M., Riederer B.M.
ISSN
0959-4965 (Print)
ISSN-L
0959-4965
Statut éditorial
Publié
Date de publication
2003
Volume
14
Numéro
7
Pages
929-933
Langue
anglais
Résumé
A panel of novel monoclonal antibodies was tested on the human entorhinal cortex for the recognition of age- and disease-related changes of neurofilament proteins (NF). Several antibodies identified phosphorylated NF-H subunit, which occurred preferentially in those aged between 60 and 80 years and were localized in degenerating neurons. Such neurons also contained neurofibrillary tangles, but neurofilament aggregates did not co-localize with tangles, nor did the quantity nor the number of NF-positive neurons correlate with the severity of Alzheimer's disease. This points to a susceptibility of NF in a subset of neurons for phosphorylation- and metabolically related morphological changes during neurodegeneration.
Mots-clé
Aged, Aged, 80 and over, Entorhinal Cortex/chemistry, Entorhinal Cortex/metabolism, Female, Humans, Male, Middle Aged, Nerve Degeneration/metabolism, Nerve Degeneration/pathology, Neurodegenerative Diseases/metabolism, Neurofilament Proteins/analysis, Neurofilament Proteins/metabolism, Neurons/chemistry, Neurons/metabolism, Phosphorylation, Subcellular Fractions/chemistry, Subcellular Fractions/metabolism, tau Proteins/analysis, tau Proteins/metabolism
Pubmed
Web of science
Création de la notice
24/01/2008 15:34
Dernière modification de la notice
20/08/2019 13:33
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