Article: article from journal or magazin.
Differential subcellular localization of phosphorylated neurofilament and tau proteins in degenerating neurons of the human entorhinal cortex.
A panel of novel monoclonal antibodies was tested on the human entorhinal cortex for the recognition of age- and disease-related changes of neurofilament proteins (NF). Several antibodies identified phosphorylated NF-H subunit, which occurred preferentially in those aged between 60 and 80 years and were localized in degenerating neurons. Such neurons also contained neurofibrillary tangles, but neurofilament aggregates did not co-localize with tangles, nor did the quantity nor the number of NF-positive neurons correlate with the severity of Alzheimer's disease. This points to a susceptibility of NF in a subset of neurons for phosphorylation- and metabolically related morphological changes during neurodegeneration.
Aged, Aged, 80 and over, Entorhinal Cortex/chemistry, Entorhinal Cortex/metabolism, Female, Humans, Male, Middle Aged, Nerve Degeneration/metabolism, Nerve Degeneration/pathology, Neurodegenerative Diseases/metabolism, Neurofilament Proteins/analysis, Neurofilament Proteins/metabolism, Neurons/chemistry, Neurons/metabolism, Phosphorylation, Subcellular Fractions/chemistry, Subcellular Fractions/metabolism, tau Proteins/analysis, tau Proteins/metabolism
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