Long-term changes of synaptic transmission induced by arachidonic acid in the CA1 subfield of the rat hippocampus
Détails
ID Serval
serval:BIB_09143DF0CE62
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Long-term changes of synaptic transmission induced by arachidonic acid in the CA1 subfield of the rat hippocampus
Périodique
Neuroscience Letters
ISSN
0304-3940 (Print)
Statut éditorial
Publié
Date de publication
07/1990
Volume
115
Numéro
2-3
Pages
286-92
Notes
In Vitro
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jul 31
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jul 31
Résumé
The effects induced by arachidonic acid upon excitatory synaptic transmission were investigated in the CA1 subfield of rat hippocampal slices. Perfusion with medium containing 50 microM of arachidonic acid induced in 12 of 19 experiments a long-lasting potentiation of the stratum radiatum-induced responses recorded in the cell body and in the apical dendritic layers. In 5 of 19 experiments, arachidonic acid evoked a depression of the same responses. Both effects were antagonized by nordihydroguaiaretic acid which is an inhibitor of lipoxygenase enzymes. These results demonstrate that one or more than one of the arachidonic acid metabolites of the lipoxygenase pathways might be involved in the long-term modulation of synaptic transmission in the hippocampus.
Mots-clé
Action Potentials/drug effects
Animals
Arachidonic Acid
Arachidonic Acids/*pharmacology
Hippocampus/drug effects/enzymology/*physiology
Lipoxygenase/*metabolism
Male
Neuronal Plasticity/*drug effects
Nordihydroguaiaretic Acid/pharmacology
Rats
Rats, Inbred Strains
Pubmed
Web of science
Création de la notice
24/01/2008 14:17
Dernière modification de la notice
20/08/2019 13:31