Long-term changes of synaptic transmission induced by arachidonic acid in the CA1 subfield of the rat hippocampus

Details

Serval ID
serval:BIB_09143DF0CE62
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Long-term changes of synaptic transmission induced by arachidonic acid in the CA1 subfield of the rat hippocampus
Journal
Neuroscience Letters
Author(s)
Drapeau  C., Pellerin  L., Wolfe  L. S., Avoli  M.
ISSN
0304-3940 (Print)
Publication state
Published
Issued date
07/1990
Volume
115
Number
2-3
Pages
286-92
Notes
In Vitro
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jul 31
Abstract
The effects induced by arachidonic acid upon excitatory synaptic transmission were investigated in the CA1 subfield of rat hippocampal slices. Perfusion with medium containing 50 microM of arachidonic acid induced in 12 of 19 experiments a long-lasting potentiation of the stratum radiatum-induced responses recorded in the cell body and in the apical dendritic layers. In 5 of 19 experiments, arachidonic acid evoked a depression of the same responses. Both effects were antagonized by nordihydroguaiaretic acid which is an inhibitor of lipoxygenase enzymes. These results demonstrate that one or more than one of the arachidonic acid metabolites of the lipoxygenase pathways might be involved in the long-term modulation of synaptic transmission in the hippocampus.
Keywords
Action Potentials/drug effects Animals Arachidonic Acid Arachidonic Acids/*pharmacology Hippocampus/drug effects/enzymology/*physiology Lipoxygenase/*metabolism Male Neuronal Plasticity/*drug effects Nordihydroguaiaretic Acid/pharmacology Rats Rats, Inbred Strains
Pubmed
Web of science
Create date
24/01/2008 13:17
Last modification date
20/08/2019 12:31
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