Inter-embryo gene expression variability recapitulates the hourglass pattern of evo-devo.

Détails

Ressource 1Télécharger: 32950053_BIB_076B6D0800A4.pdf (1173.10 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_076B6D0800A4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Inter-embryo gene expression variability recapitulates the hourglass pattern of evo-devo.
Périodique
BMC biology
Auteur(s)
Liu J., Frochaux M., Gardeux V., Deplancke B., Robinson-Rechavi M.
ISSN
1741-7007 (Electronic)
ISSN-L
1741-7007
Statut éditorial
Publié
Date de publication
19/09/2020
Peer-reviewed
Oui
Volume
18
Numéro
1
Pages
129
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
The evolution of embryological development has long been characterized by deep conservation. In animal development, the phylotypic stage in mid-embryogenesis is more conserved than either early or late stages among species within the same phylum. Hypotheses to explain this hourglass pattern have focused on purifying the selection of gene regulation. Here, we propose an alternative-genes are regulated in different ways at different stages and have different intrinsic capacities to respond to perturbations on gene expression.
To eliminate the influence of natural selection, we quantified the expression variability of isogenetic single embryo transcriptomes throughout fly Drosophila melanogaster embryogenesis. We found that the expression variability is lower at the phylotypic stage, supporting that the underlying regulatory architecture in this stage is more robust to stochastic variation on gene expression. We present evidence that the phylotypic stage is also robust to genetic variations on gene expression. Moreover, chromatin regulation appears to play a key role in the variation and evolution of gene expression.
We suggest that a phylum-level pattern of embryonic conservation can be explained by the intrinsic difference of gene regulatory mechanisms in different stages.
Mots-clé
Evo-devo, Expression variability, Hourglass
Pubmed
Open Access
Oui
Financement(s)
Fonds national suisse / Projets / 31003A_153341
Fonds national suisse / Projets / 31003A_173048
SEFRI / AgingX
Création de la notice
22/09/2020 16:01
Dernière modification de la notice
30/04/2021 7:08
Données d'usage