Inter-embryo gene expression variability recapitulates the hourglass pattern of evo-devo.

Details

Serval ID
serval:BIB_076B6D0800A4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Inter-embryo gene expression variability recapitulates the hourglass pattern of evo-devo.
Journal
BMC biology
Author(s)
Liu J., Frochaux M., Gardeux V., Deplancke B., Robinson-Rechavi M.
ISSN
1741-7007 (Electronic)
ISSN-L
1741-7007
Publication state
Published
Issued date
19/09/2020
Peer-reviewed
Oui
Volume
18
Number
1
Pages
129
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
The evolution of embryological development has long been characterized by deep conservation. In animal development, the phylotypic stage in mid-embryogenesis is more conserved than either early or late stages among species within the same phylum. Hypotheses to explain this hourglass pattern have focused on purifying the selection of gene regulation. Here, we propose an alternative-genes are regulated in different ways at different stages and have different intrinsic capacities to respond to perturbations on gene expression.
To eliminate the influence of natural selection, we quantified the expression variability of isogenetic single embryo transcriptomes throughout fly Drosophila melanogaster embryogenesis. We found that the expression variability is lower at the phylotypic stage, supporting that the underlying regulatory architecture in this stage is more robust to stochastic variation on gene expression. We present evidence that the phylotypic stage is also robust to genetic variations on gene expression. Moreover, chromatin regulation appears to play a key role in the variation and evolution of gene expression.
We suggest that a phylum-level pattern of embryonic conservation can be explained by the intrinsic difference of gene regulatory mechanisms in different stages.
Keywords
Evo-devo, Expression variability, Hourglass
Pubmed
Open Access
Yes
Funding(s)
Swiss National Science Foundation / Projects / 31003A_153341
Swiss National Science Foundation / Projects / 31003A_173048
SERI (SEFRI) / AgingX
Create date
22/09/2020 16:01
Last modification date
23/09/2020 6:26
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