Biodistribution, dosimetry, and clinical evaluation of technetium-99m ethyl cysteinate dimer in normal subjects and in patients with chronic cerebral infarction

Détails

ID Serval
serval:BIB_05A37A6C2E7E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Biodistribution, dosimetry, and clinical evaluation of technetium-99m ethyl cysteinate dimer in normal subjects and in patients with chronic cerebral infarction
Périodique
Journal of Nuclear Medicine
Auteur(s)
Holman  B. L., Hellman  R. S., Goldsmith  S. J., Mena  I. G., Leveille  J., Gherardi  P. G., Moretti  J. L., Bischof-Delaloye  A., Hill  T. C., Rigo  P. M., Vanheertum  R. L., Ell  P.J., Buell  U., Deroo  M. C., Morgan  R. A.
ISSN
0161-5505 (Print)
Statut éditorial
Publié
Date de publication
06/1989
Volume
30
Numéro
6
Pages
1018-24
Notes
Clinical Trial Journal Article Multicenter Study --- Old month value: Jun
Résumé
Technetium-99m ethyl cysteinate dimer (ECD) has high initial cerebral uptake with slow clearance in nonhuman primates suggesting ideal characteristics for single photon emission computer tomography (SPECT) imaging. We evaluated the biodistribution, dosimetry and scintigraphic pattern of [99mTc]ECD in normal subjects and the accuracy of SPECT imaging in patients with chronic cerebral infarction. Sixteen normal subjects were injected with approximately 10 mCi of [99mTc]ECD. Anterior and posterior single-pass whole-body images were obtained at multiple times after injection. Blood clearance of the radiotracer was rapid, falling to 10.0 +/- 6.6% and 4.9 +/- 1.1% of the injected dose at 2 and 60 min, respectively. Brain uptake was 6.4 +/- 2.1% of the injected dose 5 min after injection. The critical organ was the urinary bladder. Technetium-99m ECD SPECT was performed with a rotating gamma camera in ten of the 16 normal subjects and 34 patients with clinical and CT evidence of chronic stroke. Thirty-three of the thirty-four patients had focal [99mTc]ECD abnormalities on SPECT (97.1%) based on visual inspection of the SPECT images. In summary, we obtained high quality SPECT images as a result of the optimal physical and biologic characteristics of the tracer. Technetium-99m ECD SPECT shows promise for the evaluation of patients with stroke.
Mots-clé
Cerebral Infarction/metabolism/*radionuclide imaging Chronic Disease Cysteine/*analogs & derivatives/diagnostic use/pharmacokinetics Female Humans Male Multicenter Studies Organometallic Compounds/*diagnostic use/pharmacokinetics *Organotechnetium Compounds Radiation Dosage Reference Values Tissue Distribution *Tomography, Emission-Computed
Pubmed
Web of science
Création de la notice
25/01/2008 11:21
Dernière modification de la notice
20/08/2019 12:27
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