Biodistribution, dosimetry, and clinical evaluation of technetium-99m ethyl cysteinate dimer in normal subjects and in patients with chronic cerebral infarction

Details

Serval ID
serval:BIB_05A37A6C2E7E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Biodistribution, dosimetry, and clinical evaluation of technetium-99m ethyl cysteinate dimer in normal subjects and in patients with chronic cerebral infarction
Journal
Journal of Nuclear Medicine
Author(s)
Holman  B. L., Hellman  R. S., Goldsmith  S. J., Mena  I. G., Leveille  J., Gherardi  P. G., Moretti  J. L., Bischof-Delaloye  A., Hill  T. C., Rigo  P. M., Vanheertum  R. L., Ell  P.J., Buell  U., Deroo  M. C., Morgan  R. A.
ISSN
0161-5505 (Print)
Publication state
Published
Issued date
06/1989
Volume
30
Number
6
Pages
1018-24
Notes
Clinical Trial Journal Article Multicenter Study --- Old month value: Jun
Abstract
Technetium-99m ethyl cysteinate dimer (ECD) has high initial cerebral uptake with slow clearance in nonhuman primates suggesting ideal characteristics for single photon emission computer tomography (SPECT) imaging. We evaluated the biodistribution, dosimetry and scintigraphic pattern of [99mTc]ECD in normal subjects and the accuracy of SPECT imaging in patients with chronic cerebral infarction. Sixteen normal subjects were injected with approximately 10 mCi of [99mTc]ECD. Anterior and posterior single-pass whole-body images were obtained at multiple times after injection. Blood clearance of the radiotracer was rapid, falling to 10.0 +/- 6.6% and 4.9 +/- 1.1% of the injected dose at 2 and 60 min, respectively. Brain uptake was 6.4 +/- 2.1% of the injected dose 5 min after injection. The critical organ was the urinary bladder. Technetium-99m ECD SPECT was performed with a rotating gamma camera in ten of the 16 normal subjects and 34 patients with clinical and CT evidence of chronic stroke. Thirty-three of the thirty-four patients had focal [99mTc]ECD abnormalities on SPECT (97.1%) based on visual inspection of the SPECT images. In summary, we obtained high quality SPECT images as a result of the optimal physical and biologic characteristics of the tracer. Technetium-99m ECD SPECT shows promise for the evaluation of patients with stroke.
Keywords
Cerebral Infarction/metabolism/*radionuclide imaging Chronic Disease Cysteine/*analogs & derivatives/diagnostic use/pharmacokinetics Female Humans Male Multicenter Studies Organometallic Compounds/*diagnostic use/pharmacokinetics *Organotechnetium Compounds Radiation Dosage Reference Values Tissue Distribution *Tomography, Emission-Computed
Pubmed
Web of science
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25/01/2008 11:21
Last modification date
20/08/2019 12:27
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