Targeting of secretory IgA to Peyer's patch dendritic and T cells after transport by intestinal M cells.

Détails

ID Serval
serval:BIB_059C9FA09817
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Targeting of secretory IgA to Peyer's patch dendritic and T cells after transport by intestinal M cells.
Périodique
Journal of Immunology
Auteur(s)
Rey J., Garin N., Spertini F., Corthésy B.
ISSN
0022-1767[print], 0022-1767[linking]
Statut éditorial
Publié
Date de publication
2004
Volume
172
Numéro
5
Pages
3026-3033
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Résumé
In addition to being instrumental to the protection of mucosal epithelia, secretory IgA (SIgA) adheres to and is transported by intestinal Peyer's patch (PP) M cells. The possible functional reason for this transport is unknown. We have thus examined in mice the outcome of SIgA delivered from the intestinal lumen to the cells present in the underlying organized mucosa-associated lymphoreticular tissue. We show selective association of SIgA with dendritic cells and CD4(+) T and B lymphocytes recovered from PP in vitro. In vivo, exogenously delivered SIgA is able to enter into multiple PP lining the intestine. In PP, SIgA associates with and is internalized by dendritic cells in the subepithelial dome region, whereas the interaction with CD4(+) T cells is limited to surface binding. Interaction between cells and SIgA is mediated by the IgA moiety and occurs for polymeric and monomeric molecular forms. Thus, although immune exclusion represents the main function of SIgA, transport of the Ab by M cells might promote Ag sampling under neutralizing conditions essential to the homeostasis of mucosal surfaces.
Mots-clé
Animals, Binding Sites, Antibody, Cell Separation, Dendritic Cells/immunology, Dendritic Cells/metabolism, Endocytosis/immunology, Flow Cytometry, Immunoglobulin A, Secretory/administration &amp, dosage, Immunoglobulin A, Secretory/metabolism, Injections, Intraperitoneal, Intestinal Mucosa/cytology, Intestinal Mucosa/immunology, Ligation, Mice, Peyer's Patches/cytology, Peyer's Patches/immunology, Protein Binding/immunology, Protein Transport/immunology, Receptors, Antigen, B-Cell/metabolism, Secretory Component/metabolism, T-Lymphocyte Subsets/immunology, T-Lymphocyte Subsets/metabolism
Pubmed
Web of science
Création de la notice
25/01/2008 14:53
Dernière modification de la notice
20/08/2019 12:27
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