Plasma concentrations of cytokines, their soluble receptors, and antioxidant vitamins can predict the development of multiple organ failure in patients at risk

Détails

ID Serval
serval:BIB_054CDDB80A5E
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Plasma concentrations of cytokines, their soluble receptors, and antioxidant vitamins can predict the development of multiple organ failure in patients at risk
Périodique
Critical Care Medicine
Auteur(s)
Borrelli  E., Roux-Lombard  P., Grau  G. E., Girardin  E., Ricou  B., Dayer  J., Suter  P. M.
ISSN
0090-3493
Statut éditorial
Publié
Date de publication
03/1996
Peer-reviewed
Oui
Volume
24
Numéro
3
Pages
392-7
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Mar
Résumé
OBJECTIVES: The aims of this study were: a) to evaluate plasma concentrations of cytokines and their soluble receptors, as well as antioxidant substances in patients at high risk of developing multiple organ failure; b) to investigate early change: and c) to examine the possible prognostic value of these elements. DESIGN: Prospective analysis. SETTING: Surgical intensive care unit (ICU) of a university hospital. PATIENTS: sixteen patients at risk for multiple organ failure. MEASUREMENTS AND MAIN RESULTS: Ten patients developed multiple organ failure and five of them died. Whereas tumor necrosis factor-alpha (TNF-alpha) plasma concentrations were only borderline higher in patients developing multiple organ failure, TNF-soluble receptors 55 and 75 were significantly increased during all ICU days compared with patients not going into organ failure. Interleukin-6 plasma concentrations were higher in patients developing multiple organ failure during the first 2 days after ICU admission. The antioxidant vitamin C was significantly decreased in patients going into multiple organ failure during all ICU days. Other biochemical markers of antioxidant activity, such as vitamin E, copper, and zinc plasma concentrations, did not differ between the two groups. CONCLUSIONS: Our data suggest that there is a marked increase in anti-TNF activity and a decrease of antioxidant defense in patients at risk of developing multiple organ failure. The predictive value of plasma concentrations of circulating TNF-soluble receptors and vitamin C in this type of patient needs further evaluation.
Mots-clé
Adult Aged Analysis of Variance Antioxidants/*analysis Cytokines/*blood Female Humans Male Middle Aged Multiple Organ Failure/*blood Prognosis Prospective Studies Receptors, Cytokine/*analysis Risk Factors Solubility Vitamins/*blood
Pubmed
Web of science
Création de la notice
15/01/2008 15:28
Dernière modification de la notice
20/08/2019 13:27
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