Plasma concentrations of cytokines, their soluble receptors, and antioxidant vitamins can predict the development of multiple organ failure in patients at risk

Details

Serval ID
serval:BIB_054CDDB80A5E
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Plasma concentrations of cytokines, their soluble receptors, and antioxidant vitamins can predict the development of multiple organ failure in patients at risk
Journal
Critical Care Medicine
Author(s)
Borrelli  E., Roux-Lombard  P., Grau  G. E., Girardin  E., Ricou  B., Dayer  J., Suter  P. M.
ISSN
0090-3493
Publication state
Published
Issued date
03/1996
Peer-reviewed
Oui
Volume
24
Number
3
Pages
392-7
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Mar
Abstract
OBJECTIVES: The aims of this study were: a) to evaluate plasma concentrations of cytokines and their soluble receptors, as well as antioxidant substances in patients at high risk of developing multiple organ failure; b) to investigate early change: and c) to examine the possible prognostic value of these elements. DESIGN: Prospective analysis. SETTING: Surgical intensive care unit (ICU) of a university hospital. PATIENTS: sixteen patients at risk for multiple organ failure. MEASUREMENTS AND MAIN RESULTS: Ten patients developed multiple organ failure and five of them died. Whereas tumor necrosis factor-alpha (TNF-alpha) plasma concentrations were only borderline higher in patients developing multiple organ failure, TNF-soluble receptors 55 and 75 were significantly increased during all ICU days compared with patients not going into organ failure. Interleukin-6 plasma concentrations were higher in patients developing multiple organ failure during the first 2 days after ICU admission. The antioxidant vitamin C was significantly decreased in patients going into multiple organ failure during all ICU days. Other biochemical markers of antioxidant activity, such as vitamin E, copper, and zinc plasma concentrations, did not differ between the two groups. CONCLUSIONS: Our data suggest that there is a marked increase in anti-TNF activity and a decrease of antioxidant defense in patients at risk of developing multiple organ failure. The predictive value of plasma concentrations of circulating TNF-soluble receptors and vitamin C in this type of patient needs further evaluation.
Keywords
Adult Aged Analysis of Variance Antioxidants/*analysis Cytokines/*blood Female Humans Male Middle Aged Multiple Organ Failure/*blood Prognosis Prospective Studies Receptors, Cytokine/*analysis Risk Factors Solubility Vitamins/*blood
Pubmed
Web of science
Create date
15/01/2008 14:28
Last modification date
20/08/2019 12:27
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