Measuring the neuromodulatory effects of drugs in man with positron emission tomography.

Détails

ID Serval
serval:BIB_051D0BA13702
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Measuring the neuromodulatory effects of drugs in man with positron emission tomography.
Périodique
Neuroscience Letters
Auteur⸱e⸱s
Friston K.J., Grasby P.M., Bench C.J., Frith C.D., Cowen P.J., Liddle P.F., Frackowiak R.S., Dolan R.
ISSN
0304-3940 (Print)
ISSN-L
0304-3940
Statut éditorial
Publié
Date de publication
1992
Volume
141
Numéro
1
Pages
106-110
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
Cognitive activation in conjunction with pharmacological challenge was used to demonstrate neuromodulation in man. Using positron emission tomography (PET), measurements of regional cerebral blood flow were made during the performance of memory tasks, before and after the administration of apomorphine (dopamine agonist), buspirone (5-HT1A partial agonist) or placebo. Drug effects on memory-induced increases in regional cerebral blood flow were assessed, on a voxel-by-voxel basis, using statistical parametric mapping. Increases of regional cerebral blood flow in response to the memory challenge were attenuated by apomorphine in the dorsolateral prefrontal cortex and augmented in the retrosplenial region of the posterior cingulate. Conversely, buspirone attenuated blood flow increases in the retrosplenial region. These interactions between drugs and a cognitive challenge can best be interpreted as neuromodulatory effects.
Mots-clé
Adult, Animals, Apomorphine/pharmacology, Brain/radionuclide imaging, Brain Chemistry/drug effects, Brain Mapping, Buspirone/pharmacology, Cerebrovascular Circulation/drug effects, Cognition/drug effects, Frontal Lobe/drug effects, Frontal Lobe/physiology, Hippocampus/drug effects, Hippocampus/physiology, Humans, Memory/drug effects, Neurotransmitter Agents/pharmacology, Psychomotor Performance/drug effects, Rabbits, Stereotaxic Techniques, Tomography, Emission-Computed
Pubmed
Web of science
Création de la notice
25/09/2011 16:08
Dernière modification de la notice
20/08/2019 12:26
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