Measuring the neuromodulatory effects of drugs in man with positron emission tomography.

Details

Serval ID
serval:BIB_051D0BA13702
Type
Article: article from journal or magazin.
Collection
Publications
Title
Measuring the neuromodulatory effects of drugs in man with positron emission tomography.
Journal
Neuroscience Letters
Author(s)
Friston K.J., Grasby P.M., Bench C.J., Frith C.D., Cowen P.J., Liddle P.F., Frackowiak R.S., Dolan R.
ISSN
0304-3940 (Print)
ISSN-L
0304-3940
Publication state
Published
Issued date
1992
Volume
141
Number
1
Pages
106-110
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
Cognitive activation in conjunction with pharmacological challenge was used to demonstrate neuromodulation in man. Using positron emission tomography (PET), measurements of regional cerebral blood flow were made during the performance of memory tasks, before and after the administration of apomorphine (dopamine agonist), buspirone (5-HT1A partial agonist) or placebo. Drug effects on memory-induced increases in regional cerebral blood flow were assessed, on a voxel-by-voxel basis, using statistical parametric mapping. Increases of regional cerebral blood flow in response to the memory challenge were attenuated by apomorphine in the dorsolateral prefrontal cortex and augmented in the retrosplenial region of the posterior cingulate. Conversely, buspirone attenuated blood flow increases in the retrosplenial region. These interactions between drugs and a cognitive challenge can best be interpreted as neuromodulatory effects.
Keywords
Adult, Animals, Apomorphine/pharmacology, Brain/radionuclide imaging, Brain Chemistry/drug effects, Brain Mapping, Buspirone/pharmacology, Cerebrovascular Circulation/drug effects, Cognition/drug effects, Frontal Lobe/drug effects, Frontal Lobe/physiology, Hippocampus/drug effects, Hippocampus/physiology, Humans, Memory/drug effects, Neurotransmitter Agents/pharmacology, Psychomotor Performance/drug effects, Rabbits, Stereotaxic Techniques, Tomography, Emission-Computed
Pubmed
Web of science
Create date
25/09/2011 16:08
Last modification date
20/08/2019 12:26
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