Hemocompatibility of a coaxial pump catheter for less invasive heart surgery.

Détails

ID Serval
serval:BIB_034BCD25B677
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Hemocompatibility of a coaxial pump catheter for less invasive heart surgery.
Périodique
Perfusion
Auteur⸱e⸱s
Mueller X.M., Augstburger M., Boone Y., von S.
ISSN
0267-6591
Statut éditorial
Publié
Date de publication
2002
Peer-reviewed
Oui
Volume
17
Numéro
1
Pages
3-7
Langue
anglais
Résumé
Off-pump coronary artery bypass (OPCAB) requires heart manipulation during exposure of the lateral and posterior walls of the heart, which may cause hemodynamic instability, mainly through right ventricular dysfunction. A coaxial atrial cannula connected to a minicentrifugal pump was developed to bypass the right heart. This study was designed to test the hemocompatibility of this pump ongoing for 6 h. In five calves (bodyweight, 70.3+/-4.2 kg), the pump was inserted and set to its maximal motor speed of 7000 rpm. Blood samples were taken for blood gas analyses, hematology and chemistry on an hourly basis. ANOVA was used for statistical analysis. During the 6-h run, hematocrit and red blood cell count were stable (p=0.77 and 0.87, respectively). Platelet count was not significantly altered (p=0.55). LDH was stable (p=0.61) and plasma free hemoglobin remained below 100 mg/l throughout the experiment. Adequate tissue perfusion was maintained as reflected by the stable mixed venous oxygen saturation (baseline, 72.5+/-2%, and 6 h, 65.6+/-3.4%) and no defect of any pump system was detected during this 6-h testing. This right heart minipump appears to have a minimal impact on red cells and platelets when set at its maximal speed for 6 h, underlining the hematological safety of the system.
Mots-clé
Animals, Blood Cells/chemistry, Blood Cells/cytology, Cardiac Surgical Procedures/methods, Cardiac Surgical Procedures/standards, Cardiopulmonary Bypass/instrumentation, Cardiopulmonary Bypass/standards, Catheterization/instrumentation, Catheterization/standards, Cattle, Equipment Design, Hematocrit, Hemodynamics, Materials Testing
Pubmed
Web of science
Création de la notice
14/02/2008 14:16
Dernière modification de la notice
20/08/2019 12:25
Données d'usage