Hemocompatibility of a coaxial pump catheter for less invasive heart surgery.

Details

Serval ID
serval:BIB_034BCD25B677
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Hemocompatibility of a coaxial pump catheter for less invasive heart surgery.
Journal
Perfusion
Author(s)
Mueller X.M., Augstburger M., Boone Y., von S.
ISSN
0267-6591
Publication state
Published
Issued date
2002
Peer-reviewed
Oui
Volume
17
Number
1
Pages
3-7
Language
english
Abstract
Off-pump coronary artery bypass (OPCAB) requires heart manipulation during exposure of the lateral and posterior walls of the heart, which may cause hemodynamic instability, mainly through right ventricular dysfunction. A coaxial atrial cannula connected to a minicentrifugal pump was developed to bypass the right heart. This study was designed to test the hemocompatibility of this pump ongoing for 6 h. In five calves (bodyweight, 70.3+/-4.2 kg), the pump was inserted and set to its maximal motor speed of 7000 rpm. Blood samples were taken for blood gas analyses, hematology and chemistry on an hourly basis. ANOVA was used for statistical analysis. During the 6-h run, hematocrit and red blood cell count were stable (p=0.77 and 0.87, respectively). Platelet count was not significantly altered (p=0.55). LDH was stable (p=0.61) and plasma free hemoglobin remained below 100 mg/l throughout the experiment. Adequate tissue perfusion was maintained as reflected by the stable mixed venous oxygen saturation (baseline, 72.5+/-2%, and 6 h, 65.6+/-3.4%) and no defect of any pump system was detected during this 6-h testing. This right heart minipump appears to have a minimal impact on red cells and platelets when set at its maximal speed for 6 h, underlining the hematological safety of the system.
Keywords
Animals, Blood Cells/chemistry, Blood Cells/cytology, Cardiac Surgical Procedures/methods, Cardiac Surgical Procedures/standards, Cardiopulmonary Bypass/instrumentation, Cardiopulmonary Bypass/standards, Catheterization/instrumentation, Catheterization/standards, Cattle, Equipment Design, Hematocrit, Hemodynamics, Materials Testing
Pubmed
Web of science
Create date
14/02/2008 14:16
Last modification date
20/08/2019 12:25
Usage data