Identification of a high concentration of scyllo-inositol in the brain of a healthy human subject using 1H- and 13C-NMR.

Détails

ID Serval
serval:BIB_02F3B58F2D95
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Identification of a high concentration of scyllo-inositol in the brain of a healthy human subject using 1H- and 13C-NMR.
Périodique
Magnetic Resonance in Medicine
Auteur(s)
Seaquist E.R., Gruetter R.
ISSN
0740-3194 (Print)
ISSN-L
0740-3194
Statut éditorial
Publié
Date de publication
1998
Volume
39
Numéro
2
Pages
313-316
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.Publication Status: ppublish
Résumé
The peak at 3.35 ppm in the 1H-NMR spectrum characteristic for scyllo-inositol may be a marker for cerebral pathology, although it has a well-known constant concentration relative to myo-inositol. Such a peak was observed with an intensity at least 300% above normal in the brain of a healthy volunteer. The scyllo-inositol signal was assigned based on the detection of a corresponding peak at 74.5 ppm in the 13C-NMR spectrum and on the demonstration of singlet characteristics of the proton signal. The presence of substantial brain concentrations of scyllo-inositol suggests that scyllo-inositol metabolism may be regulated independently from myo-inositol and that such concentrations are compatible with normal health.
Mots-clé
Adult, Brain/metabolism, Brain Chemistry, Humans, Inositol/metabolism, Magnetic Resonance Spectroscopy/diagnostic use, Male, Stereoisomerism
Pubmed
Web of science
Création de la notice
04/08/2010 15:28
Dernière modification de la notice
20/08/2019 12:25
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