Article: article from journal or magazin.
Identification of a high concentration of scyllo-inositol in the brain of a healthy human subject using 1H- and 13C-NMR.
Magnetic Resonance in Medicine
Publication types: Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.Publication Status: ppublish
The peak at 3.35 ppm in the 1H-NMR spectrum characteristic for scyllo-inositol may be a marker for cerebral pathology, although it has a well-known constant concentration relative to myo-inositol. Such a peak was observed with an intensity at least 300% above normal in the brain of a healthy volunteer. The scyllo-inositol signal was assigned based on the detection of a corresponding peak at 74.5 ppm in the 13C-NMR spectrum and on the demonstration of singlet characteristics of the proton signal. The presence of substantial brain concentrations of scyllo-inositol suggests that scyllo-inositol metabolism may be regulated independently from myo-inositol and that such concentrations are compatible with normal health.
Adult, Brain/metabolism, Brain Chemistry, Humans, Inositol/metabolism, Magnetic Resonance Spectroscopy/diagnostic use, Male, Stereoisomerism
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