Thymoma, immunodeficiency, and herpes simplex virus infections.

Détails

Ressource 1Télécharger: BIB_02437680064E.P001.pdf (171.53 [Ko])
Etat: Public
Version: Author's accepted manuscript
ID Serval
serval:BIB_02437680064E
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Thymoma, immunodeficiency, and herpes simplex virus infections.
Périodique
Médecine et Maladies Infectieuses
Auteur(s)
Méan M., Schaller M.D., Asner S., Meylan P., Pagani J.L., Tarr P., Eggimann P.
ISSN
0399-077X
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
39
Numéro
5
Pages
344-347
Langue
anglais
Résumé
Hypogammaglobulinemia develops in 3 to 6% of patients with thymoma and this association is commonly referred to as thymoma with immunodeficiency (formerly Good syndrome). Recurrent infections with encapsulated bacteria and opportunistic infections associated with disorders of both humoral and cell mediated immunity frequently occur in this rare primary, adult-onset immunodeficiency. We report a case of thymoma with immunodeficiency complicated by disseminated herpes simplex virus (HSV) infection and review five additional cases of HSV-related infections reported since 1966 in patients presenting with thymoma with immunodeficiency. Patients presented with epiglottitis, keratitis, recurrent genital herpes, ulcerative dermatitis, and acute hepatitis. Four of the six cases had a fatal outcome, two of which were directly attributable to HSV infection. Since the risk of invasive opportunistic infections is high and the presentation atypical, lymphocyte count and total serum immunoglobulin should be measured regularly in all patients presenting with thymoma with immunodeficiency.
Mots-clé
Adult, Aged, Ceftriaxone/therapeutic use, Fatal Outcome, Female, Herpes Simplex/complications, Humans, Immunoglobulins/blood, Immunologic Deficiency Syndromes/complications, Male, Middle Aged, Thymoma/complications, Thymoma/pathology, Thymus Neoplasms/complications, Thymus Neoplasms/pathology
Pubmed
Web of science
Open Access
Oui
Création de la notice
18/03/2009 7:48
Dernière modification de la notice
16/10/2019 10:52
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