Iron oxide-enhanced MR lymphography: initial experience.

Details

Serval ID
serval:BIB_FFAB82B61EC5
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Iron oxide-enhanced MR lymphography: initial experience.
Journal
European Journal of Radiology
Author(s)
Bellin M.F., Beigelman C., Precetti-Morel S.
ISSN
0720-048X (Print)
ISSN-L
0720-048X
Publication state
Published
Issued date
2000
Volume
34
Number
3
Pages
257-264
Language
english
Notes
Publication types: Journal Article ; Review
Abstract
The detection of nodal metastases is of utmost importance in oncologic imaging. Ultrasmall superparamagnetic iron oxide particles (USPIO) are novel contrast agents specifically developed for MR lymphography. After intravenous administration, they are taken up by the macrophages of the lymph nodes, where they accumulate. They reduce the signal intensity (SI) of normally functioning nodes on postcontrast T2-and T2*-weighted images through the magnetic susceptibility effects on iron oxide. Metastatic nodes, in which macrophages are replaced by tumor cells, show no significant change in SI on postcontrast T2-and T2*-weighted images. Early clinical experience suggests that USPIO-enhanced MR lymphography improves the sensitivity and specificity for the detection of nodal metastases. It also suggests that micrometastases could be detected in normal-sized nodes. This article reviews the physiochemical properties of USPIO contrast agents, their enhancement patterns, and early clinical experience.
Keywords
Contrast Media, Humans, Injections, Intravenous, Iron Compounds/administration & dosage, Iron Compounds/adverse effects, Lymphatic Metastasis/diagnosis, Lymphography/methods, Magnetic Resonance Imaging/methods, Neoplasm Staging
Pubmed
Create date
31/08/2011 12:46
Last modification date
20/08/2019 16:29
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