Iron oxide-enhanced MR lymphography: initial experience.

Détails

ID Serval
serval:BIB_FFAB82B61EC5
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Iron oxide-enhanced MR lymphography: initial experience.
Périodique
European Journal of Radiology
Auteur(s)
Bellin M.F., Beigelman C., Precetti-Morel S.
ISSN
0720-048X (Print)
ISSN-L
0720-048X
Statut éditorial
Publié
Date de publication
2000
Volume
34
Numéro
3
Pages
257-264
Langue
anglais
Notes
Publication types: Journal Article ; Review
Résumé
The detection of nodal metastases is of utmost importance in oncologic imaging. Ultrasmall superparamagnetic iron oxide particles (USPIO) are novel contrast agents specifically developed for MR lymphography. After intravenous administration, they are taken up by the macrophages of the lymph nodes, where they accumulate. They reduce the signal intensity (SI) of normally functioning nodes on postcontrast T2-and T2*-weighted images through the magnetic susceptibility effects on iron oxide. Metastatic nodes, in which macrophages are replaced by tumor cells, show no significant change in SI on postcontrast T2-and T2*-weighted images. Early clinical experience suggests that USPIO-enhanced MR lymphography improves the sensitivity and specificity for the detection of nodal metastases. It also suggests that micrometastases could be detected in normal-sized nodes. This article reviews the physiochemical properties of USPIO contrast agents, their enhancement patterns, and early clinical experience.
Mots-clé
Contrast Media, Humans, Injections, Intravenous, Iron Compounds/administration & dosage, Iron Compounds/adverse effects, Lymphatic Metastasis/diagnosis, Lymphography/methods, Magnetic Resonance Imaging/methods, Neoplasm Staging
Pubmed
Création de la notice
31/08/2011 12:46
Dernière modification de la notice
20/08/2019 16:29
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