A roadmap for driving CAR T cells toward the oncogenic immunopeptidome.

Details

Serval ID
serval:BIB_FF0839215AF4
Type
Article: article from journal or magazin.
Publication sub-type
Letter (letter): Communication to the publisher.
Collection
Publications
Institution
Title
A roadmap for driving CAR T cells toward the oncogenic immunopeptidome.
Journal
Cancer cell
Author(s)
Irving M., Zoete V., Bassani-Sternberg M., Coukos G.
ISSN
1878-3686 (Electronic)
ISSN-L
1535-6108
Publication state
Published
Issued date
10/01/2022
Peer-reviewed
Oui
Volume
40
Number
1
Pages
20-22
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
A critical barrier to CAR T cell therapy is the paucity of target antigens that are broadly and stably expressed exclusively in tumors. In their comprehensive multi-omics and pre-clinical study, Yarmarkovich et al. provide proof of principle for the development and efficacy of peptide centric (PC)-CARs targeting the oncogenic immunopeptidome of neuroblastoma.
Pubmed
Web of science
Create date
17/01/2022 10:16
Last modification date
02/03/2022 7:34
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