Interplays between mouse mammary tumor virus and the cellular and humoral immune response.

Details

Serval ID
serval:BIB_FD0A307D70FA
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Interplays between mouse mammary tumor virus and the cellular and humoral immune response.
Journal
Immunological Reviews
Author(s)
Acha-Orbea H., Finke D., Attinger A., Schmid S., Wehrli N., Vacheron S., Xenarios I., Scarpellino L., Toellner K.M., MacLennan I.C., Luther S.A.
ISSN
0105-2896 (Print)
ISSN-L
0105-2896
Publication state
Published
Issued date
1999
Volume
168
Pages
287-303
Language
english
Abstract
Mouse mammary tumor virus has developed strategies to exploit the immune response. It requires vigorous immune stimulation to achieve efficient infection. The infected antigen-presenting cells present a viral superantigen on the cell surface which stimulates strong CD4-mediated T-cell help but CD8 T-cell responses are undetectable. Despite the high frequency of superantigen-reactive T cells, the superantigen-induced immune response is comparable to classical antigen responses in terms of T-cell priming, T-cell-B-cell collaboration as well as follicular and extra-follicular B-cell differentiation. Induction of systemic anergy is observed, similar to classical antigen responses where antigen is administered systemically but does not influence the role of the superantigen-reactive T cells in the maintenance of the chronic germinal center reaction. So far we have been unable to detect a cytotoxic T-cell response to mouse mammary tumor virus peptide antigens or to the superantigen. This might yet represent another step in the viral infection strategy.
Keywords
Amino Acid Sequence, Animals, Antibody Formation, Antigen-Presenting Cells/immunology, Antigens, Viral/immunology, Humans, Immunity, Cellular, Mammary Tumor Virus, Mouse/immunology, Mice, Molecular Sequence Data, Retroviridae Infections/immunology, Superantigens/immunology, T-Lymphocytes/immunology, T-Lymphocytes, Cytotoxic/immunology, Tumor Virus Infections/immunology, Virus Diseases/immunology
Pubmed
Web of science
Create date
24/01/2008 14:48
Last modification date
20/08/2019 16:28
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